Abstract

The study aimed to evaluate the sub-acute toxicity effect of aqueous N. coriacea leaves extract to kidney and liver function. The biotoxic study was conducted using male rats. In this study, the experimental animals received five different doses of aqueous N. coriacea leaves extract (0.1 mg, 1 mg,10 mg, 100 mg, and 1000 mg per day) for 4 weeks via oral route. After treatment, the level of plasma ureum, creatinine, Aspartate Transaminase (AST) and Alanine Transaminase (ALT) level were measured.

The  results  show  that  most  of  dose  treatments  of  aqueous  extract  of  N.  coriacea  leaves  had  not statistically effect on  the level of the plasma  ureum and  creatinine except for dosage of 1000  mg. Similarly, the dose treatments of that extract did not statistically change the plasma AST and ALT, except on 100 and 1000 mg/kg of b.w extract dose. In conclusion, a short-term intake of N. coriacea leaves extract via oral route was not toxic to kidney and liver.

Kata Kunci : N. Coriacea, Kidney, Liver, Toxicity

Media Publikasi :                    

Berkala Kedokteran Vol. 14 No 2, 2018

Penulis :

Iskandar Thalib, Purwanto Budi Santosa, Eko Suhartono